Ozone therapy in organ preservation and ischemia–reperfusion injury: mechanistic and translational perspectives

Authors

  • Umit Karadeli Department of Bioinformatics and Systems Biology, Canakkale Onsekiz Mart University, Canakkale, Turkey
  • Meliha M. Cicekliyurt Department of Medical Biology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey

Keywords:

Kidney transplantation, Oksidative stress, Ozone therapy, UW

Abstract

Kidney transplantation remains the best method for kidney failure. However, ischemia-reperfusion injury (I/R) is one of the main problems in graft survival. The University of Wisconsin (UW) solution, which made history with great hope, has shown its protective effect, but coping with oxidative stress is not easy. Ozone, which is frequently used in alternative medicine, has been studied as a potential adjunctive strategy in solid organ transplantation, particularly to improve organ preservation and reduce ischemia-induced damage. This review summarizes the current experimental and translational evidence regarding the potential role of ozone therapy in organ protection, organ transplantation, and the regulation of oxidative stress. Examples of transplantation and clinical applications are provided, highlighting the effects of ozone.

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Published

2026-07-14

How to Cite

[1]
Karadeli, U. and Cicekliyurt, M.M. 2026. Ozone therapy in organ preservation and ischemia–reperfusion injury: mechanistic and translational perspectives . Journal of BioScience and Biotechnology. 15, 1 (Jul. 2026), 35–43.

Issue

Vol. 15 No. 1 (2026)

Section

Genetics

License

Copyright (c) 2026 Umit Karadeli

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