Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats

Authors

  • Ibrahim Abubakar Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University Sokoto, Nigeria
  • Mu'azu Abubakar Gusau Department of Biochemistry, Faculty of Science, Usmanu Danfodiyo University Sokoto, Nigeria
  • Jabir Aliyu Danyaya Biochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, Nigeria
  • Shehu Ibrahim Department of Chemistry, Shehu Shagari University of Education, Sokoto, Nigeria
  • Zayyanu Abdullahi Biochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, Nigeria
  • Abdulhakim Zubairu Biochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, Nigeria
  • Abdulsalam Umar Sahabi Biochemistry Unit, Department of Science Technology, Waziri Umaru Federal Polytechnic, Birnin Kebbi, Nigeria

Keywords:

Acetic acid, Analgesics, Diclofenac, Hannoa klaineana, Pain

Abstract

Pain remains a major health, social, and economic problem worldwide. Hannoa klaineana Pierre & Engl. is a medicinal plant found in many African countries and used for the treatment of many diseases including pain-associated disorders. This study was conducted to evaluate the analgesic effect of the ethylacetate fraction of methanol leaf extract of Hannoa klaineana in rats. The analgesic effect of the ethylacetate fraction of methanol leaves extract of Hannoa klaineana (200, 400, and 600 mg/kg b.wt) was evaluated using acetic acid-induced writhing, tail flick (immersion), and hot plate model. In the acetic acid-induced writhing test, the extract (200, 400, and 600 mg/kg) demonstrated a significant (p < 0.05) decrease in the number of writhes with maximum percentage inhibition (75.61%) at 600 mg/kg dose of the extract. In tail flick and hot plate tests, the extract (200, 400, and 600 mg/kg b.wt) exhibited a significant (p < 0.05) increase in rats’ response with a steady increase in reaction time. Findings from this study show that ethylacetate fraction of the methanol leaves extract of Hannoa klaineana possessed analgesic activity which provided justification for the local use of the plant in the treatment of pain.

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Published

2025-01-10

How to Cite

[1]
Abubakar, I., Abubakar Gusau, M., Aliyu Danyaya, J., Ibrahim, S., Abdullahi, Z., Zubairu, A. and Umar Sahabi, A. 2025. Analgesic effect of ethylacetate fraction of the methanol leaves extract of Hannoa klaineana in rats. Journal of BioScience and Biotechnology. 13, 2 (Jan. 2025), 155–161.

Issue

Vol. 13 No. 2 (2024)

Section

Biochemistry and Biotechnology

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Copyright (c) 2024 Ibrahim Abubakar, Gusau, Danyaya, Shehu Ibrahim, Zayyanu Abdullahi, Abdulhakim Zubairu, Sahabi

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